Naqvi, F et al, Sub-chronic Exposure to Noise Affects Locomotor Activity etc.

Sub-chronic exposure to noise affects locomotor activity and produces anxiogenic and depressive like behaviour in rats.

Fizza Naqvi, Saida Haider, Zehra Batool, Tahire Perveen, Darakhshan J. Haleem

Noise is defined as a displeasing and unwanted sound. It is one of the most encountered stressor to which mankind is exposed. Frustration, poor reading, impaired hearing and difficulty in problem solving activities are the common consequences of noise stress. It has been reported to produce atrophy of dendrites and alterations in neurotransmitter levels.

Long term exposure to inescapable noise stress induces exhaustion, defeat, annoyance followed by decreased muscle movement, social contacts and mood changes.

The present study was aimed to investigate the detrimental effects of noise exposure on behaviour of rats and its association with altered neuro-chemistry.

Changes in neurotransmitter levels in different brain regions including hippocampus have been reported following noise exposure and these changes in neurotransmitters levels have also been associated with altered behaviour.

In the present study, locomotor activity in rats was assessed by open field test while anxiety and depressive behaviour was monitored by elevated plus maze and tail suspension tests. The results showed that 15 days sub-chronic exposure to noise stress induced anxiety and depression like behaviour in male rats. These behavioural deficits observed in the present study suggest that an altered brain serotonergic and dopaminergic activity may be involved in the various psychological disorders following exposure to noise stress.

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